Medicaton-Induced Nutrient Depletions
While medication has the potential to be lifesaving, some commonly
prescribed medications are known to deplete the body of various
nutrients. The chart below shows recognized nutrient depletions
associated with frequently prescribed medications and supplemental
formulas that contain those nutrients.
| Drug | Depletion | WholeScripts Consideration | References |
|---|---|---|---|
| Atenolol 100MG | Melatonin Zinc CoQ10 |
Xymogen -
Melatonin CR Davinci Labs - Liposomal Melatonin Spray Xymogen - Zinc Glycinate Allergy Research Group - Zinc Picolinate Xymogen - CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Fares A. Night-time exogenous melatonin administration may be
a beneficial treatment for sleeping disorders in beta blocker
patients. J Cardiovasc Dis Res. 2011;2(3):153-155.
doi:10.4103/0975-3583.85261
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Kishi H, Kishi T, Folkers K. Bioenergetics in clinical
medicine. III. Inhibition of coenzyme Q10-enzymes by
clinically used anti-hypertensive drugs. Res Commun Chem
Pathol Pharmacol. 1975;12(3):533-540.
|
| Atenolol 50MG | Melatonin Zinc CoQ10 |
Xymogen -
Melatonin CR Davinci Labs - Liposomal Melatonin Spray Xymogen - Zinc Glycinate Allergy Research Group - Zinc Picolinate Xymogen - CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Fares A. Night-time exogenous melatonin administration may be
a beneficial treatment for sleeping disorders in beta blocker
patients. J Cardiovasc Dis Res. 2011;2(3):153-155.
doi:10.4103/0975-3583.85261
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Kishi H, Kishi T, Folkers K. Bioenergetics in clinical
medicine. III. Inhibition of coenzyme Q10-enzymes by
clinically used anti-hypertensive drugs. Res Commun Chem
Pathol Pharmacol. 1975;12(3):533-540.
|
| Atenolol 25MG | Melatonin Zinc CoQ10 |
Xymogen -
Melatonin CR Davinci Labs - Liposomal Melatonin Spray Xymogen - Zinc Glycinate Allergy Research Group - Zinc Picolinate Xymogen - CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Fares A. Night-time exogenous melatonin administration may be
a beneficial treatment for sleeping disorders in beta blocker
patients. J Cardiovasc Dis Res. 2011;2(3):153-155.
doi:10.4103/0975-3583.85261
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Kishi H, Kishi T, Folkers K. Bioenergetics in clinical
medicine. III. Inhibition of coenzyme Q10-enzymes by
clinically used anti-hypertensive drugs. Res Commun Chem
Pathol Pharmacol. 1975;12(3):533-540.
|
| Atorvastatin 40MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Atorvastatin 20MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Azithromycin 250MG (6 tabs) - (Generic Z-PAK) | Probiotics |
Xymogen -
ProbioMax Complete DF |
Maier L, Goemans CV, Wirbel J, et al. Unravelling the
collateral damage of antibiotics on gut bacteria. Nature.
2021;599(7883):120-124. doi:10.1038/s41586-021-03986-2
|
| Citalopram 40MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Citalopram 20MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Escitalopram 20MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Escitalopram 10MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Fluoxetine 40MG (CAPS) | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Fluoxetine 20MG (CAPS) | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Gabapentin 300mg caps (qty 60) | Vitamin B12 Folate |
Xymogen -
5-MTHF Plus B12 Seeking Health - Active B12 with L-5-MTHF |
Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs
interact with folate and vitamin B12 serum levels. Ann Neurol.
2011;69(2):352-359. doi:10.1002/ana.22229
|
| Gabapentin 600mg tablets (qty 60) | Vitamin B12 Folate |
Xymogen -
5-MTHF Plus B12 Seeking Health - Active B12 with L-5-MTHF |
Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs
interact with folate and vitamin B12 serum levels. Ann Neurol.
2011;69(2):352-359. doi:10.1002/ana.22229
|
| Gabapentin 800mg tablets (qty 60) | Vitamin B12 Folate |
Xymogen -
5-MTHF Plus B12 Seeking Health - Active B12 with L-5-MTHF |
Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs
interact with folate and vitamin B12 serum levels. Ann Neurol.
2011;69(2):352-359. doi:10.1002/ana.22229
|
| Hydrochlorothiazide 50MG | Zinc Potassium Sodium Magnesium |
Xymogen -
Zinc Glycinate Allergy Research Group - Zinc Picolinate Elemental Labs - LMNT Recharge |
Cohen N, Golik A. Zinc balance and medications commonly used
in the management of heart failure. Heart Fail Rev.
2006;11(1):19-24. doi:10.1007/s10741-006-9189-1
Barber J, McKeever TM, McDowell SE, et al. A systematic review
and meta-analysis of thiazide-induced hyponatraemia: time to
reconsider electrolyte monitoring regimens after thiazide
initiation?. Br J Clin Pharmacol. 2015;79(4):566-577.
doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
van Megen WH, Grimm PR, Welling PA, van der Wijst J. Renal
sodium and magnesium reabsorption are not coupled in a mouse
model of Gordon syndrome. Physiol Rep. 2018;6(14):e13728.
doi:10.14814/phy2.13728
|
| Hydrochlorothiazide 25MG | Zinc Potassium Sodium Magnesium |
Xymogen -
Zinc Glycinate Allergy Research Group - Zinc Picolinate Elemental Labs - LMNT Recharge |
Cohen N, Golik A. Zinc balance and medications commonly used
in the management of heart failure. Heart Fail Rev.
2006;11(1):19-24. doi:10.1007/s10741-006-9189-1
Barber J, McKeever TM, McDowell SE, et al. A systematic review
and meta-analysis of thiazide-induced hyponatraemia: time to
reconsider electrolyte monitoring regimens after thiazide
initiation?. Br J Clin Pharmacol. 2015;79(4):566-577.
doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
van Megen WH, Grimm PR, Welling PA, van der Wijst J. Renal
sodium and magnesium reabsorption are not coupled in a mouse
model of Gordon syndrome. Physiol Rep. 2018;6(14):e13728.
doi:10.14814/phy2.13728
|
| Hydrochlorothiazide 12.5MG | Zinc Potassium Sodium Magnesium |
Xymogen -
Zinc Glycinate Allergy Research Group - Zinc Picolinate Elemental Labs - LMNT Recharge |
Barber J, McKeever TM, McDowell SE, et al. A systematic review
and meta-analysis of thiazide-induced hyponatraemia: time to
reconsider electrolyte monitoring regimens after thiazide
initiation?. Br J Clin Pharmacol. 2015;79(4):566-577.
doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
|
| Lisinopril/HCTZ 20MG-25MG (30 tabs) | Zinc Potassium Sodium Magnesium |
Xymogen -
Zinc Glycinate Allergy Research Group - Zinc Picolinate Elemental Labs - LMNT Recharge |
Barber J, McKeever TM, McDowell SE, et al. A systematic review
and meta-analysis of thiazide-induced hyponatraemia: time to
reconsider electrolyte monitoring regimens after thiazide
initiation?. Br J Clin Pharmacol. 2015;79(4):566-577.
doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
|
| Lisinopril/HCTZ 20MG-12.5MG (30 tabs) | Zinc Potassium Sodium Magnesium |
Xymogen -
Zinc Glycinate Allergy Research Group - Zinc Picolinate Elemental Labs - LMNT Recharge |
Barber J, McKeever TM, McDowell SE, et al. A systematic review
and meta-analysis of thiazide-induced hyponatraemia: time to
reconsider electrolyte monitoring regimens after thiazide
initiation?. Br J Clin Pharmacol. 2015;79(4):566-577.
doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a
systematic review of zinc and antihypertensive therapy. Int J
Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
|
| Metformin | Folic acid Vitamin B12 |
Xymogen -
5-MTHF Plus B12 Seeking Health - Active B12 with L-5-MTHF |
Roy RP, Ghosh K, Ghosh M, et al. Study of Vitamin B12
deficiency and peripheral neuropathy in metformin-treated
early Type 2 diabetes mellitus [published correction appears
in Indian J Endocrinol Metab. 2016 Nov-Dec;20(6):895]. Indian
J Endocrinol Metab. 2016;20(5):631-637.
doi:10.4103/2230-8210.190542
|
| Methotrexate | Glutathione Superoxide Dismutase |
Xymogen -
S-Acetyl Glutathione Quicksilver - Liposomal Glutathione |
Elbarbary NS, Ismail EA, Farahat RK, El-Hamamsy M. ω-3 fatty
acids as an adjuvant therapy ameliorates methotrexate-induced
hepatotoxicity in children and adolescents with acute
lymphoblastic leukemia: A randomized placebo-controlled study.
Nutrition. 2016;32(1):41-47. doi:10.1016/j.nut.2015.06.010
|
| Metoprolol Succ ER 100MG | Melatonin |
Xymogen -
Melatonin CR Davinci Labs - Liposomal Melatonin Spray |
Fares A. Night-time exogenous melatonin administration may be
a beneficial treatment for sleeping disorders in beta blocker
patients. J Cardiovasc Dis Res. 2011;2(3):153-155.
doi:10.4103/0975-3583.85261
|
| Metoprolol Succ ER 50MG | Melatonin |
Xymogen -
Melatonin CR Davinci Labs - Liposomal Melatonin Spray |
Fares A. Night-time exogenous melatonin administration may be
a beneficial treatment for sleeping disorders in beta blocker
patients. J Cardiovasc Dis Res. 2011;2(3):153-155.
doi:10.4103/0975-3583.85261
|
| Paroxetine 40MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Paroxetine 20MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Pravastatin 40MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Pravastatin 20MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Rosuvastatin 40MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Rosuvastatin 20MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Sertraline 100MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Sertraline 50MG | Sodium |
LMNT -
Recharge (powder) Trace Minerals - Electrolyte Stamina (tablets) BodyBIO - E-Lyte (liquid) |
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced
Hyponatremia in Older Adults. Consult Pharm.
2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
|
| Simvastatin 40MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|
| Simvastatin 20MG | CoQ10 |
Xymogen -
CoQmax Omega 100 Life Extension - Super Ubiquinol CoQ10 |
Banach M, Serban C, Ursoniu S, et al. Statin therapy and
plasma coenzyme Q10 concentrations--A systematic review and
meta-analysis of placebo-controlled trials. Pharmacol Res.
2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
|