Medicaton-Induced Nutrient Depletions

While medication has the potential to be lifesaving, some commonly prescribed medications are known to deplete the body of various nutrients. The chart below shows recognized nutrient depletions associated with frequently prescribed medications and supplemental formulas that contain those nutrients.
Drug Depletion WholeScripts Consideration References
Atenolol 100MG Melatonin Zinc CoQ10 Xymogen - Melatonin CR
Davinci Labs - Liposomal Melatonin Spray
Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Fares A. Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients. J Cardiovasc Dis Res. 2011;2(3):153-155. doi:10.4103/0975-3583.85261
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol. 1975;12(3):533-540.
Atenolol 50MG Melatonin Zinc CoQ10 Xymogen - Melatonin CR
Davinci Labs - Liposomal Melatonin Spray
Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Fares A. Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients. J Cardiovasc Dis Res. 2011;2(3):153-155. doi:10.4103/0975-3583.85261
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol. 1975;12(3):533-540.
Atenolol 25MG Melatonin Zinc CoQ10 Xymogen - Melatonin CR
Davinci Labs - Liposomal Melatonin Spray
Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Fares A. Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients. J Cardiovasc Dis Res. 2011;2(3):153-155. doi:10.4103/0975-3583.85261
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol. 1975;12(3):533-540.
Atorvastatin 40MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Atorvastatin 20MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Azithromycin 250MG (6 tabs) - (Generic Z-PAK) Probiotics Xymogen - ProbioMax Complete DF
Maier L, Goemans CV, Wirbel J, et al. Unravelling the collateral damage of antibiotics on gut bacteria. Nature. 2021;599(7883):120-124. doi:10.1038/s41586-021-03986-2
Citalopram 40MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Citalopram 20MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Escitalopram 20MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Escitalopram 10MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Fluoxetine 40MG (CAPS) Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Fluoxetine 20MG (CAPS) Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Gabapentin 300mg caps (qty 60) Vitamin B12 Folate Xymogen - 5-MTHF Plus B12
Seeking Health - Active B12 with L-5-MTHF
Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 2011;69(2):352-359. doi:10.1002/ana.22229
Gabapentin 600mg tablets (qty 60) Vitamin B12 Folate Xymogen - 5-MTHF Plus B12
Seeking Health - Active B12 with L-5-MTHF
Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 2011;69(2):352-359. doi:10.1002/ana.22229
Gabapentin 800mg tablets (qty 60) Vitamin B12 Folate Xymogen - 5-MTHF Plus B12
Seeking Health - Active B12 with L-5-MTHF
Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 2011;69(2):352-359. doi:10.1002/ana.22229
Hydrochlorothiazide 50MG Zinc Potassium Sodium Magnesium Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Elemental Labs - LMNT Recharge
Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev. 2006;11(1):19-24. doi:10.1007/s10741-006-9189-1
Barber J, McKeever TM, McDowell SE, et al. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. Br J Clin Pharmacol. 2015;79(4):566-577. doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
van Megen WH, Grimm PR, Welling PA, van der Wijst J. Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome. Physiol Rep. 2018;6(14):e13728. doi:10.14814/phy2.13728
Hydrochlorothiazide 25MG Zinc Potassium Sodium Magnesium Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Elemental Labs - LMNT Recharge
Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev. 2006;11(1):19-24. doi:10.1007/s10741-006-9189-1
Barber J, McKeever TM, McDowell SE, et al. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. Br J Clin Pharmacol. 2015;79(4):566-577. doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
van Megen WH, Grimm PR, Welling PA, van der Wijst J. Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome. Physiol Rep. 2018;6(14):e13728. doi:10.14814/phy2.13728
Hydrochlorothiazide 12.5MG Zinc Potassium Sodium Magnesium Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Elemental Labs - LMNT Recharge
Barber J, McKeever TM, McDowell SE, et al. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. Br J Clin Pharmacol. 2015;79(4):566-577. doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Lisinopril/HCTZ 20MG-25MG (30 tabs) Zinc Potassium Sodium Magnesium Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Elemental Labs - LMNT Recharge
Barber J, McKeever TM, McDowell SE, et al. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. Br J Clin Pharmacol. 2015;79(4):566-577. doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Lisinopril/HCTZ 20MG-12.5MG (30 tabs) Zinc Potassium Sodium Magnesium Xymogen - Zinc Glycinate
Allergy Research Group - Zinc Picolinate
Elemental Labs - LMNT Recharge
Barber J, McKeever TM, McDowell SE, et al. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. Br J Clin Pharmacol. 2015;79(4):566-577. doi:10.1111/bcp.12499
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-725. doi:10.1111/ijcp.12040
Metformin Folic acid Vitamin B12 Xymogen - 5-MTHF Plus B12
Seeking Health - Active B12 with L-5-MTHF
Roy RP, Ghosh K, Ghosh M, et al. Study of Vitamin B12 deficiency and peripheral neuropathy in metformin-treated early Type 2 diabetes mellitus [published correction appears in Indian J Endocrinol Metab. 2016 Nov-Dec;20(6):895]. Indian J Endocrinol Metab. 2016;20(5):631-637. doi:10.4103/2230-8210.190542
Methotrexate Glutathione Superoxide Dismutase Xymogen - S-Acetyl Glutathione
Quicksilver - Liposomal Glutathione
Elbarbary NS, Ismail EA, Farahat RK, El-Hamamsy M. ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study. Nutrition. 2016;32(1):41-47. doi:10.1016/j.nut.2015.06.010
Metoprolol Succ ER 100MG Melatonin Xymogen - Melatonin CR
Davinci Labs - Liposomal Melatonin Spray
Fares A. Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients. J Cardiovasc Dis Res. 2011;2(3):153-155. doi:10.4103/0975-3583.85261
Metoprolol Succ ER 50MG Melatonin Xymogen - Melatonin CR
Davinci Labs - Liposomal Melatonin Spray
Fares A. Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients. J Cardiovasc Dis Res. 2011;2(3):153-155. doi:10.4103/0975-3583.85261
Paroxetine 40MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Paroxetine 20MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Pravastatin 40MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Pravastatin 20MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Rosuvastatin 40MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Rosuvastatin 20MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Sertraline 100MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Sertraline 50MG Sodium LMNT - Recharge (powder)
Trace Minerals - Electrolyte Stamina (tablets)
BodyBIO - E-Lyte (liquid)
Viramontes TS, Truong H, Linnebur SA. Antidepressant-Induced Hyponatremia in Older Adults. Consult Pharm. 2016;31(3):139-150. doi:10.4140/TCP.n.2016.139
Simvastatin 40MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008
Simvastatin 20MG CoQ10 Xymogen - CoQmax Omega 100
Life Extension - Super Ubiquinol CoQ10
Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-336. doi:10.1016/j.phrs.2015.07.008